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PAPER SELECTED

Osteocalcin: A biochemical marker of bone formation in equine medicine

GRAFENAU P, CARSTANJEN B, LEPAGE OM
Veterinarni Medicina 45, 2000, 209-216

Osteocalcin is the most abundant non-collagenous bone protein. It is produced by osteoblasts and is accepted as a biochemical marker of bone formation. The authors summarize the current knowledge of physicochemical properties, biosynthesis and functional aspects of osteocalcin in various species. In addition, determinants of plasma/serum osteocalcin concentration in the equine species are described. Factors affecting blood osteocalcin concentration recognized in horses are: age, type of horse, circadian rhythm, season, administration of exogenous corticosteroids and general anesthesia. In combination with osteocalcin measurements the kidney function should always be evaluated because it is the main way for osteocalcin clearance. Serum/plasma osteocalcin measurements are used in horses for training evaluation, for diagnostic purpose and to monitor the effect of a medical therapy on equine bone


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