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Apoptosis of polymorphonuclear leukocytes

SLADEK Z, RYSANEK D
Veterinarni Medicina 44, 1999, 309-320

Polymorphonuclear leukocytes play the major role in the phagocytary system of defence against bacterial infection. Their life span is the shortest among all leukocytes. After leaving the blood circulation, they are predestined for programmed cell death - apoptosis. Unlike necrosis, apoptosis does not induce damage to tissues due to the histotoxic potential of granules of the polymorphonuclear leukocytes. The review summarizes principal opinions and results of experimental work on basic morphological, biochemical and genetic aspects of this type of cell death in polymorphonuclear leukocytes, as well as on factors controlling this process


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