A pilot study of 1-hydroxypyrene in the urine of pigs and cows

Veterinarni Medicina 44, 1999, 359-363

In 1990, the Government of the Czech Republic included the area surrounding the town of Hodonin among the 17 regions with the highest environmental pollution rates. Urine samples for the determination of l-hydroxypyrene as a metabolite of pyrene were collected from fatteners and sows at three swine farms and from dairy cows at two farms in the district of Hodonin in May 1999. In human medicine, the urinary 1-hydroxypyrene is regarded as a biomarker of exposure to polycyclic aromatic hydrocarbons. The set under study included 20 samples collected from fatteners (females and castrated males aged from 200 to 220 days), 10 samples collected from breeding sows (age from 2 to 3 years), and 19 samples collected from dairy cows (age from 3 to 4 years). All the samplings were done between 6.00 and 7.00 a.m. Mean concentrations of the urinary 1-hydroxypyrene for the two cattle farms were 12.07 and 24.51 mu g/l, respectively, and for the three swine farms 0.23, 0.44, and 0.06 mu g/l. The mean concentration was higher (p < 0.05) in sows than in fatteners (0.54 vs. 0.11 mu g/l). No significant difference in the concentration of urinary 1-hydroxypyrene was found between females and castrated males (0.08 vs. 0.14 mu g/1) Further research will be focused on the assessment of urinary 1-hydroxypyrene concentrations as a biomarker of exposure of pigs and cows to polycyclic aromatic hydrocarbons

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