Alternatives for nematode control in connection with anthelmintic resistance

Veterinarni Medicina 44, 1999, 83-89

Short introduction to chemotherapy as well as a list of the most frequently used anthelmintics are given in the first part of the paper. Chemotherapy has been used as the only means of parasite control in many cases, which results in development of resistance of some nematode parasites to anthelmintic drugs. Furthermore, there is a considerable problem of residues both in animal tissues and on pasture. Options for other chemotherapeutical approaches, in case that anthelmintic resistance occurs, are discussed (using another drug, combinations of drugs, possibilities of reversion to susceptibility, prospects for development of new drugs). The main goal of the paper is to introduce non-chemotherapeutical methods for helminth control - vaccines against helminths, genetic approaches (selection for helminth-resistant hosts and genetic manipulations of the parasite), alternative chemicals (growth regulators), biological control (nematophagous fungi). However, the most of these methods are in the stage of intensive research and it probably takes some time before they become a part of reliable helminth control systems. Therefore, there are a few short recommendations presented how to maintain the sufficient efficacy of anthelmintics and to prevent or delay the development of anthelmintic resistance

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