Impairment of neutrophil and lymphocyte functions in dogs with uncomplicated and pyoderma complicated demodicosis

Veterinarni Medicina 44, 1999, 19-24

The objective of investigation was to determine the degree of phagocytic ability of neutrophils and lymphocyte blastogenesis in dogs with different duration of uncomplicated localized (LD) and generalized (GD) demodicosis, in comparison with the values in dogs with demodicosis complicated with pyoderma and the clinically normal dogs. At the time of analysis, the dogs received no medical therapy. Pyoderma was detected in the group of dogs which exhibited GD over five weeks from the appearance of clinical signs. Depression of phagocytic activity (% of phagocytosis) and ingestion capacity (index of phagocytic activity) have been demonstrated in the dogs suffering from GD, but not in the LD dogs. Neutrophil dysfunction depended on the duration of clinical signs manifestation. Neutrophils from the dogs with pyoderma complicated GD exhibited significantly lower ingestion capacity than those from the dogs with uncomplicated GD. II was proposed that the presence of bacterial infection may be related to the neutrophil alteration initiated by demodicosis. Lymphocyte blastogenesis suppression to Con A accompanied not only uncomplicated GD, but also LD. This immunosuppression develops with the duration of clinical disease. Lymphocytes from the dogs with uncomplicated GD and pyoderma complicated GD responded to Con A equally, however their response was significantly lower in comparison with the control. We do not assume that the immunosuppression in the investigated dogs with complicated CD was due to the secondary bacterial infection. In conclusion, the dysfunction of both lymphocytes and neutrophils could predispose to the development of secondary pyoderma, a common sequela to generalized demodicosis

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