Immunological parameters in dogs with juvenile panostitis

Veterinarni Medicina 44, 1999, 13-18

A set of immunological tests, expressing the activity of both cellular and humoral immunity, was used to examine peripheral blood samples collected from thirty canine patients suffering from juvenile panostitis. Sixteen dogs were sampled before and fourteen different dogs during the treatment. Increased numbers of eosinophilic and neutrophilic granulocytes were found in 43.3% and 23.3% of the patients, respectively. An increase in the concentration of blood serum lysozyme, reduced activity in the lymphocyte blastic transformation test and an increased number of monocytes were demonstrated in 16.7%, 10% and 6.7% of them, respectively. A comparison of mean values among group of normal dogs and of patients sampled before, or during the treatment period showed significant differences in test of chemiluminiscence and in levels of circulating immunocomplexes and lysozyme. These differences reflect probably secondary changes associated with the inflammation. It is concluded that, generally, the immune system is not significantly involved in the pathogenesis of canine panostitis. Possible local effects were not detectable by the set of tests used in our investigation

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