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PAPER SELECTED

Insertion sequences of mycobacteria and their use in the study of epidemiology of mycobacterial infections

DVORSKA L, HAVELKOVA M, BARTOS M, BARTL J, PAVLIK I
Veterinarni Medicina 44, 1999, 233-251

The current studies on human and veterinary epidemiology have highly contributed to the detection of specific, small and mobile elements of the DNA - insertion sequences (IS). These sequences were: IS900 in Mycobacterium avium subspecies paratuberculosis, IS6110 in M. tuberculosis, and IS901 in M. avium complex. It has been ten years since the discovery of mycobacterial insertion Sequences. Accordingly, the aim of this abstract was to present a summary of various research aspects and utilization of insertion sequences in mycobacteriology. The discovery, composition and function of IS are described in the introduction part. Priority has been given to the insertion sequences found in M. avium complex: IS902, IS1245, IS1311, IS1110, IS1141, IS1613


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