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A new lipoid adjuvant: Harmlessness and local reactogenicity

BENISEK Z, SULIOVA J, SVRCEK S, PAUER T, ONDREJKA R , DUROVE A
Veterinarni Medicina 44, 1999, 101-108

Model experiments on laboratory animals (guinea pigs) were carried out to test the possible allergy reaction (possibility or sensitization) to the repeated administration of an experimental lipoid adjuvant (ELA) prepared on the basis of isopropylpalmitate. No significant differences were observed between the animals senzitized-provoked with ELA and the control animals. In older to evaluate the local tissue reactivity (local reactogenicity), also with regard to the process dynamics, to the administration of ELA and to carry out comparisons with other types of lipoid adjuvants, as well as aluminium hydroxide, comparative patho-anatomical and patho-histological examinations of tissues were carried out in the location of adjuvant administration. The examinations indicated very low local reactogenicity of the experimental lipoid adjuvant prepared in our laboratory


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