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Lysine-salicylate based antipyretic in clinical and laboratory evaluation of tolerance in calves

LEHOCKY J, NAGY O, KOVAC G
Veterinarni Medicina 43, 1998, 1-6

In clinical experiments with 26 clinically healthy calves, 2 to 4 months old, Black Spotted Lowland, Slovakian Spotted cattle and their breeds of live weight 60 to 85 kg, clinical and laboratory methods were used to study the effect of combined antipyretic preparation lysine-salicylate (LS) with 20% content of salicylic acid and I-lysine (Biotika, a.s., Slovenska Lupca, SR) on the local and total tolerance, changes of triad values (body temperature, breath and heart rates), parameters of haematological (Er - erythrocyte counts, Lc - leucocyte counts, Hb - haemoglobin concentration, Hk - haematocrit value) and acid-base blood profile (pH, CO2, BE - base excess, SB - standard bicarbonate) and their possible changes from the side of circadian effects were compared. Haematological examinations were performed on automatic analyzer of blood cells SERONO system 150 and blood for acid-base analysis was examined on the apparatus ABL 4, manufactured by Radiometer Copenhagen, Denmark. Calves divided into three groups were examined by intramuscularily administered LS in the dose 0.5 ml per 1 kg of live weight (group 1, n = 11), by the same dose of physiological solution (FR, group 2, n = 9) and calves without examination (group 3, n = 6). Maximum applied dose of preparations per 1 site of administration was 20 ml. Intramuscular LS administration, similar to FR, induced short-time (1-1.5 minute) psychomotoric uneasiness (3 calves in group 1, 2 calves in group II) without significant influence on the triad value or clinically detectable reaction of site of administration. Dynamics of the triad values in calves of all groups (Tab. I) did not exceed physiological standards, including consideration of daily rhythms. Haematological profile (Figs. 1-4) in evaluated time intervals showed significant differences neither in calves of different groups, nor among groups, except leukocytes whose counts significantly increased six hours after LS administration (group 1, p < 0.01) with subsequent decrease on eighth hour of observation. insignificant changes were also found in evaluation of parameters of acid-base profile, which in groups and among groups with small fluctuations ranged within initial values. The total values of clinical and metabolic reactions of calves to LS administration as efficient antipyretic in the given therapeutic dose confirmed its good tolerance as well as unburdening effect on studied parameters of internal medium


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