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Histological and functional alterations in the endometrium of cows with persisting ovarian cysts

KUMMER V, MASKOVA J, ZRALY Z, CANDERLE J, VEZNIK Z
Veterinarni Medicina 43, 1998, 97-104

Histological and functional alterations in the endometrium of 35 cows with persisting ovarian cysts were assessed considering the hormonal pattern and length of duration of the ovarian dysfunction. Bioptic samples of endometrium were collected repeatedly at intervals of 14 to 21 days or after slaughter along with blood sampling for the determination by RIA of progesterone, 17 beta oestradiol, triiodothyronine, thyroxine and cortisol. Up to postpartum day 40, the effects of persisting follicular cysts on endometrium corresponded to the pattern of prolonged oestrogenization, including flux, hyperaemia, haemorrhages, intensive cell infiltration, particularly by lymphocytes, vacuolar degeneration of epithelial cells, incipient dilatation of uterine glands and hyperplasia of stroma in stratum compactum. The above processes became more intensive and took larger areas between postpartum days 40 and 60. This applied particularly to hyperplasia of glands and stroma and endometrial vascularization. Glandular hyperplasia, hyperaemia and cell infiltration receded from postpartum day 80 and irreversible lesions, including cystic dilatation of glands associated with dystrophy or atrophy of epithelium, periglandular fibrosis, reduction in the number of glands, intensive vascularization and vessel wall hypertrophy, diffuse Fibrosis, and endometrial atrophy began to dominate from postpartum days 100 to 120. Analyses of the obtained data have shown that the dominant role in the development of the endometrial lesions was played by oestrogens and the length of duration of the ovarian endocrinopathy


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