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Effect of free and liposomized albendazole on the immune responses in healthy and Toxocara canis-infected mice

BOROSKOVA Z, DVOROZNAKOVA E, DUBINSKY P, VELEBNY S, TOMASOVICOVA O, MACHNICKA B
Veterinarni Medicina 43, 1998, 293-300

The effect of free and liposomized albendazole on the lymphoproliferative activity was studied in healthy and Toxocara canis-infected mice. The level of specific circulating antibodies was simultaneously assessed in infected animals. A replicated administration of drug-free liposomes to healthy mice considerably reduced the response of T and B cells to non-specific polyclonal activators (Concanavalin A, Lipopolysaccharide, Pokeweed mitogen). Liposomes with incorporated albendazole, administered at a dose of 10 mg/kg b.w. twice a day for 5 days, also suppressed the same cell population activity in healthy mice. On the contrary, free albendazole given to healthy animals stimulated their T- and B-cell activity to polyclonal activators. After infection of mice with T. canis, the proliferative activity of both cell populations and the level of specific circulating antibodies were enhanced. A therapy of infected mice with liposomized albendazole partially inhibited the lymphocyte proliferative activity and the level of specific circulating antibodies fell significantly compared with only infected animals. The efficacy of liposomized albendazole against T. ca,lis larvae in the muscles during the myotropo-neurotropic phase of their migration was 41.6 to 60.8% and in the brain 52.4 to 60.8%


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