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PAPER SELECTED

The effectiveness of inactivated, purified and concentrated experimental rabies vaccine for veterinary use: Antigenic activity. Experiments on domestic dogs

BENISEK Z, SULIOVA J, SVRCEK S, ZAVADOVA J, ONDREJKA R, DUROVE A
Veterinarni Medicina 43, 1998, 45-49

The antigenic activity of experimental inactivated, concentrated, purified adjuvant rabies vaccine prepared by the authors was investigated in experiments on domestic dogs and compared with antigenic activity of commercial rabies preparations at intramuscular application. The effectiveness of experimental vaccine was tested in domestic dogs also by non-traditional intradermal method of application at varying doses (0.1 and 0.2 cm(3)). The results of determination of tables antibodies by means of VNT and ELISA method at intramuscular administration of vaccines revealed that the antigenic activity of the experimental vaccine is comparable with that of commercial preparations. The effectiveness of the experimental vaccine at intradermal administration at a dose of 0.2 cm(3) was even higher. The level of rabies antibodies was sufficient after as many as 15 months following the intradermal administration of vaccine: in none of the experimental animals any values were detected. The dose of 0.1 cm(3), administered intradermally, cannot ensure adequate antirabies protection for the period of 15 months


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