The Effect of Rabbit Age on Some Pharmacokinetic Parameters of Oxytetracycline and Rolitetracycline

Veterinarni Medicina 36, 1991, 119-127

The effect of rabbit age in the Californian White breed was investigated on oxytetra cycline and rolitetracycline concentrations in the blood serum and soft tissues, and on the biological half-life of the given antibiotics. The animals were at the age shortly before sexual maturity or they had reached sexual maturity. Oxytetracycline was administered in form of the preparation Oxymykoin inj. a. u. v. Spofa and rolitetracycline nitrate in form of the preparation Rolitetracycline inj. Spofa. These tetracyclines were administered intramuscularly at a single dose of 20 mg per kg liveweight. In comparison with adult animals, in young rabbits the starting concentrations of the two tetracyclines in the blood (first hour) were statistically insignificantly higher

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