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The influence of prolonged starvation on changes in activity of selected adaptive enzymes in rat liver

TOROPILA M, AHLERS I, AHLERSOVA E, ONDRASOVIC M, BENOVA K
Veterinarni Medicina 41, 1996, 41-44

Male rats of Wistar SPF strain (Velaz Prague) were used to investigate the influence of prolonged starvation on changes in the activity of selected adaptive enzymes in the liver and corticosterone in serum. Analyses were carried out on days 1, 2, 3, 5 and 7 of starvation. The activity of tyrosine aminotransferase significantly increased in the period between days 2 and 5 of starvation, after which a decrease to the level of satiated animals was observed in the terminal period. Activities of tryptophane-2-3-dioxygenase and alanine aminotransferase increased in two phases reaching maximum values on days 2 and 7 of starvation. The activity of aspartate aminotransferase showed a progressive significant increase in dependence on the length of starvation. A more than threefold increase in corticosterone concentration was observed in the serum of starved animals in comparison with satiated rats


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