Electron microscopy - Tool to diagnostic pathology

Veterinarni Medicina 41, 1996, 191-195

This review suggests electron microscopy applications, particularly for leucocyte surface antigens, tumors and viruses in relation to diagnostic pathology. It also describes the use of conventional staining method such as negative stain and recently developed immunocytochemistry with colloidal gold labelling significantly improved diagnostic value of electron microscopy. The examples have been chosen to demonstrate quantitative aspects in the early recognition of immunopathological states, morphological aspects in identification of both tumors and viruses, preparative techniques of specimens where the method has been widely used and immunogold labelling, including various colloidal gold systems to map specific ligands

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