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PAPER SELECTED

The effect of silymarin on concentration and total content of nucleic acids in tissues of continuously irradiated rats

HAKOVA H, MISUROVA E, KROPACOVA K
Veterinarni Medicina 41, 1996, 113-119

The effect of the hepatoprotective drug silymarin (Flavobion) on the radiation injury of rats continuously irradiated with gamma rays (Co-60) was studied. The rats were irradiated during 14 days by the dose rates of 0.2 and 0.6 Gy/day. In the course of irradiation the animals were treated with silymarin twice daily (70 mg/kg p.o. by tube). Silymarin effect was evaluated on the basis of quantitative changes of nucleic acids in the regenerating liver (after 70% hepatectomy), spleen, bone marrow and blood. Silymarin administration in the course of continuous gamma irradiation influenced beneficially the radiation-induced changes of DNA and RNA especially in the bone marrow


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