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PAPER SELECTED

Immunogenic and Antigenic Activity of An Experimental Oral Rabies Vaccine Prepared from the Strain Vnukovo-32/107

SVRCEK S, DUROVE A, ONDREJKA R, ZAVADOVA J, SULIOVA J, BENISEK Z, VRTIAK OJ, FEKETEOVA J, MADAR M
Veterinarni Medicina 40, 1995, 87-96

The immunogenic and antigenic activity of an experimental live oral rabies vaccine prepared from the strain Vnukovo-32/107 was evaluated on the basis of results obtained in 3 sets of experiments. These were carried out as model experiments on white mice, then on target animals - red foxes (Vulpes vulpes) and a related species - farm-bred polar foxes (Alopex lagopus). For quantitative determination of the immunogenic activity of the orally or subcutaneously administered rabies vaccines in model experiments on mice a method was used that had been developed in our laboratory. Antibodies were detected and quantified by an ELISA kit that had also been developed in our lab. Tenacity of the experimental vaccine (infectious tissue culture medium after yolk addition) was verified at different temperatures


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