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Cytochromes P450 - Toxicological Significance of Level Determination

MACHALA M
Veterinarni Medicina 38, 1993, 739-750

Drug-metabolizing enzymes, especially cytochrome P450-dependent monooxygenases, are involved in the metabolic activation of the majority of xenobiotics and in the production of oxygen radicals. The most significant are cytochromes P450IA1 and IA2, but also P450IIB, IIE and IIIA are involved. Various classes of xenobiotics induce levels of distinct P450 forms. Their key position in the expression of toxic, mutagenic, carcinogenic and other adverse effects of reactive metabolites and oxygen radicals allows us: 1. to estimate the tetrachlorodibenzo-p-dioxin-like toxicity in both environmental mixtures and individual contaminants by the measurement of induction of P450IA1


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