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PAPER SELECTED

Anthelmintic Control of Multiple Resistant Gastrointestinal Nematodes in Imported Goats

CORBA J, VARADY M, PRASLICKA J, VESELY L
Veterinarni Medicina 38, 1993, 369-374

Multiple resistant strains of Ostertagia and Trichostrongylus were detected in a flock of cashmere and angora goats imported from New Zealand. The ED50 values detected by in vitro EHA test were from 0.27 to 0.36 mug/ml (while the reference value of sensitivity is 0.10 mug/ml TBZ). Multiple resistance to all the types of currently used anthelmintics was confirmed by in vivo FECRT, when the efficacy of recommended doses was lower than 90 % (albendazole 74 %, levamisole 86 %, ivermectin 83 %). Two control schemes were investigated. In the simultaneous application of anthelmintics in the double or triple of recommended doses (0.4 mg/kg ivermectin s.c., 30 mg/kg levamisole and 20 mg/kg albendazole p. o.) was effective. Examination of goats 7 and 8 months after treatment revealed the repeated presence of multiple resistant gastrointestinal nematodes. It is the first published case of intercontinental transfer of resistant strains of nematodes when importing small ruminants


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